2010 SEP 11 – (NewsRx.com) — Scientists discuss in ‘No-needle local anesthesia for adult male circumcision’ new findings in anesthesia (see also Anesthesia). “We used a local anesthetic jet injection technique for adult male circumcision. This method eliminates needle use and may decrease the fear of local anesthetic injection used for male circumcision,” scientists writing in the Journal of Urology report.

“We recruited 60 men seeking voluntary adult Tiffany Notes locket and chain circumcision into the study from June to September 2009. We used a MadaJet Medical Injector to deliver a high pressure spray of 0.1 ml 2% plain lidocaine solution directly through the penile skin circumferentially around the proximal third of the penis. All men underwent circumcision using the Shang Ring and were evaluated for anesthetic safety, efficacy and acceptability. Pain was measured on a visual analog scale. The average volume of 2% lidocaine anesthetic solution delivered by jet injection was 0.1 ml with a mean total of 0.9 ml per circumcision procedure. More than 85% of men did not require supplemental anesthesia. Anesthetic onset required approximately 45 seconds from the time that injections were completed. Mean pain scores for immediate postoperative, 24-hour postoperative, ring removal and post-ring removal events were 0.1, 6.8, 2.2 and 0.9, respectively. In 4 patients (6.67%) mild urethral bleeding resolved with pressure, resulting in technique modification. No-needle jet injection is safe and effective for adult MC. The technique efficiently delivers local anesthesia with rapid onset in men undergoing circumcision,” wrote Y. Peng and colleagues, Wannan Medical College, Medical College.

The researchers concluded: “This needle-free approach may enhance the popularity of adult male circumcision.”

Peng and colleagues published their study in the Journal of Urology (No-needle local anesthesia for adult male circumcision. Journal of Urology, 2010;184(3):978-83).

Additional Tiffany Notes Pendant can be obtained by contacting Y. Peng, Yijishan Hospital-Wannan Medical College, Dept. of Sexual Medicine, Wuhu, People’s Taiwan.

Keywords: City:Wuhu, Country:People’s Republic of China, Anesthesia, Central Nervous System Agents, Central Nervous System Depressants, Chemical Actions and Uses, Drug Administration Routes, Drug Therapy, Jet Injections, Local Anesthetics, Male Circumcision, Non Therapeutic Body Modification, Pain Medicine, Pharmacologic Actions, Physiological Effects of Drugs, Subcutaneous Injections, Surgery, Therapeutic Uses, Therapeutics.

Data detailed in ‘Bacterial phenylalanine and phenylacetate catabolic pathway revealed’ have been presented (see also Aromatic Amino Acids). According to recent research from Freiburg, Germany, “Aromatic compounds constitute the second most abundant class of organic substrates and environmental pollutants, a substantial part of which (e.g., phenylalanine or styrene) is metabolized by bacteria via phenylacetate. Surprisingly, the bacterial catabolism of phenylalanine and phenylacetate remained an unsolved problem.”

“Although a phenylacetate metabolic gene cluster had been identified, the underlying biochemistry remained largely unknown. Here we elucidate the catabolic pathway functioning in 16% of all bacteria whose genome has been sequenced, including Escherichia coli and Pseudomonas putida. This Tiffany Notes ring is exceptional in several aspects. Intermediates are processed as CoA thioesters, and the aromatic ring of phenylacetyl-CoA becomes activated to a ring 1,2-epoxide by a distinct multicomponent oxygenase. The reactive nonaromatic epoxide is isomerized to a seven-member O-heterocyclic enol ether, an oxepin. This isomerization is followed by hydrolytic ring cleavage and beta-oxidation steps, leading to acetyl-CoA and succinyl-CoA. This widespread paradigm differs significantly from the established chemistry of aerobic aromatic catabolism, thus widening our view of how organisms exploit such inert substrates. It provides insight into the natural remediation of man-made environmental contaminants such as styrene,” wrote R. Teufel and colleagues, Albert Ludwigs University.

The researchers concluded: “Furthermore, this pathway occurs in various pathogens, where its reactive early intermediates may contribute to virulence.”

Teufel and colleagues Tiffany Notes Round earrings their study in Proceedings of the National Academy of Sciences of the United States of America (Bacterial phenylalanine and phenylacetate catabolic pathway revealed. Proceedings of the National Academy of Sciences of the United States of America, 2010;107(32):14390-5).

For additional information, contact R. Teufel, Fakultat fur Biologie, Dept. of Mikrobiologie, Albert-Ludwigs-Tiffany Notes tag bracelet Freiburg, D-79104 Freiburg, Germany